Nootropics - Resveratrol

Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or if the plant is under attack by pathogens.

Benefits:

• acting as antioxidant, protecting the body against risks of cancer and heart disease;
• limits the spread of cancer cells and it is killing them;
• reduce inflammation;
• lover LDL and prevents clots to form (avoiding heart attack);
• may ease joint pain;
• may protect nerve cells from damage and fight the plaque build-up leading to Alzheimer's;
• helps in diabetes preventing insulin resistance;
• sirtuins can be activated by resveratrol.

Side effects:

• might interact with blood thinners like warfarin, aspirin and ibuprofen;
• raise the chance of bleeding.

Dosage:

• in the research group was used 2000 mg, but the commercial ones contain only 250-500 mg. 

Nootropics - Nicotinamide Riboside

Nicotinamide Riboside is a precursor to NAD+ (nicotinamide adenine nucleotide). It is a nucleoside made out of niacinamide and ribose. It is a form of the vitamin B3.

Benefits:

• it is an anti-aging and help support healthy circadian rhythm;
• generate energy in mitochondrial dense tissues like muscle, brain and liver;
• protects the mitochondria, improve the mitochondria function and health;
• increase the amplitude of your circadian rhythm (fluctuation of cellular production that coordinate the day-night cycle - poor circadian rhythm lead to lower levels of NAP-MT enzyme, resulting in lower NAD+ levels);
• NAD+ activates the sirtuins * (antiaging enzymes), PARPs (repairs the damaged cells - anticancer effect) and CD38 receptor in the immune system (involved in the glucose-induced insulin secretion-reducing the diabetic symptoms);
• supports tissues that heavily relies on mitochondria for energy (nervous system, heart, liver, muscle);
• rapidly restore muscle mass;
• protects the brain (protects nerve cells by activating Sirt3(r) and PGC1a(r) pathways);
• protects the liver (stopping the fat accumulation, lowering oxidative stress, preventing inflammation and improving insulin sensitivity);
• increase the metabolism and energy use, increase the level of enzymes involved in burning fat;
• helps reprogram dysfunctional cells, increasing longevity.

Side effects:

• worsen the physical performance (lowest adverse effects - 1000 mg/day, no adverse effect -300 mg/day)

Dosage:

• at 1000 mg, effects start to feel after 6 pills, if you take 2 per day.

* Sirtuins are a family of proteins that act predominantly as NAD-dependent deacetylases. We got Sirt3, Sirt4 and Sirt5 - localized exclusively in mitochondria. Sirtuins are influencing ageing, transcription (DNA copy), apoptosis (programmed cellular death), inflammation, stress resistance, as well as energy efficiency and alertness. During low calorie situations, the sirtuins will control the circadian clock and the mitochondrial biogenesis.